Evaluation of Mast Cell Stabilizing and Anti-Anaphylactic Activity of Polyherbal Formulation
نویسندگان
چکیده
Novel polyherbal formulation (PHE) containing mainly the ethanolic extract of Adhatoda vasica Nees. (leaf), Clerodendrum serratum Linn. (root), Curcuma longa Linn. (rhizome), Solanum xanthocarpum Schrad & Wendl. (fruit) and Piper longum Linn. (fruit). HPTLC analysis of the herbal extracts of PHE revealed presence of 0.25%w/w vasicine, 3.4%w/w piperine, 1.56%w/w curcumin and 0.04%w/w solasodine. The mast cell stabilizing and anti-anaphylactic property of PHE was investigated against compound 48/80-induced mast cell degranulation as well as triple antigen-induced anaphylaxis in rats. PHE produced significant reduction in the mortality of rats subjected to triple antigen-induced anaphylactical shock. PHE also depicted marked protection of rat mesenteric mast cells from disruption by compound 48/80 in dose dependant manner. Our data suggest anti-anaphylactic and mast cell stabilizing property of PHE.
منابع مشابه
Anti-inflammatory, Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica
Objective(s) Aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. In the present study different extracts of roots of A. indica were evaluated for their antiinflammatory, antipruritic and mast cell stabilizing activity. Materials and Methods Anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and ...
متن کاملAntianaphylactic, mast cell stabilizing and antiasthmatic activity of AHR-1 (a polyherbal formulation)
Objective: This work was mainly aimed to study the anti-anaphylactic, mast cell stabilizing and antiasthmatic activity of AHR-1 (a polyherbal formulation) which contain various herbal extracts. Methods: The antianaphylactic activity of AHR-1 was evaluated in rats using active anaphylaxis model.Rats were then observed for onset of symptoms of anaphylaxis reaction such as increased respiratory ra...
متن کاملPharma Science Monitor an International Journal of Pharmaceutical Sciences Evaluation of Polyherbal Formulation, Routack, in Rodent Models of Anaphylaxis
ABSTRACT Anaphylaxis is a condition presenting with significant morbidity in sensitized individuals. IgE cross linking, degranulation of mast cells and release of preformed mediators are the pathophysiologic sequences responsible behind the anaphylactic turmoil. Adrenaline rescue is the only available therapy which can salvage an individual from an anaphylactic attack. Other concurrent therapie...
متن کاملAnti-Anaphylactic and Anti-Inflammatory Activities of a Bioactive Alkaloid from the Root Bark of Plumeria acutifolia Poir
In the present study, anti-anaphylactic, anti-inflammatory and membrane stabilizing properties of a lupine alkaloid plumerianine (compound 1), isolated from the root bark of Plumeria acutifolia Poir were investigated in animal models. The anti-anaphylactic activity of compound 1 (10, 25 and 50 mg/Kg) was studied by using models such as passive cutaneous anaphylaxis, passive paw anaphylaxis and ...
متن کاملAnti-Anaphylactic and Anti-Inflammatory Activities of a Bioactive Alkaloid from the Root Bark of Plumeria acutifolia Poir
In the present study, anti-anaphylactic, anti-inflammatory and membrane stabilizing properties of a lupine alkaloid plumerianine (compound 1), isolated from the root bark of Plumeria acutifolia Poir were investigated in animal models. The anti-anaphylactic activity of compound 1 (10, 25 and 50 mg/Kg) was studied by using models such as passive cutaneous anaphylaxis, passive paw anaphylaxis and ...
متن کامل